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Gower, Timothy. "Diabetes and Cholesterol Medications." 05 March 2007. HowStuffWorks.com. <http://health.howstuffworks.com/diabetes-and-cholesterol-medications.htm> 17 May 2008.
Inside This Article
Diabetes and Statins
Once upon a time, you could watch television for an evening or read an entire magazine without seeing a commercial or ad for a statin drug. But the ubiquity of these heavily promoted cholesterol-lowering medications has had a major payoff: Doctors say the widespread use of statins has contributed heavily to an overall drop in total cholesterol and LDL cholesterol among adults in the United States since the drugs were introduced in the 1990s. Studies show that statins slash the risk of heart attack by about 30 percent.
Officially known as HMG CoA reductase inhibitors, statins knock out an enzyme the liver needs to make cholesterol. They also encourage the liver to reabsorb more LDL cholesterol, which we all know is the "bad" kind. Studies show that these drugs can decrease LDL cholesterol up to 36 percent in diabetes patients. Sharp-eyed readers may be thinking: Why should I care, since people with diabetes don't necessarily have super-high LDL in the first place?
Maybe not, but people with diabetes do have high concentrations of small, dense LDL cholesterol particles, which are more likely to plug up arteries. Statins wipe out all LDL particles, including the dangerous kind.
And that's not all. Statins also lower triglycerides, though not as effectively as they decrease LDL cholesterol. The drugs also cause a slight uptick in HDL cholesterol, and that's good news, too. In fact, scientists from other disciplines are studying whether statins fight other diseases, including various forms of cancer.
Doctors who treat heart disease are so grateful for the lives saved by statins that they sometimes suggest adding the drugs to our nation's drinking water. And they're only half kidding. Unfortunately, while these cholesterol crushers are considered quite safe, they carry a few risks. Some are mild and short term, such as gastrointestinal problems, headaches, and a rash. However, statins may also irritate the liver, so your doctor will keep tabs on it with occasional blood tests.
More controversially, statins have been linked to several conditions, particularly myositis (swelling of the muscles) and rhabdomyolysis ( a breakdown of muscle fibers, which are then released into the circulation). Although they are rarely fatal, these conditions can cause muscle pain, cramps, and weakness. However, studies suggest that these problems are not very common. A 2003 survey in the Journal of the American Medical Association estimated that one to five percent of patients who take statins develop some form of muscle pain or weakness. What's more, the problem may be triggered by taking some other medication (such as fibrates and niacin; see below) with a statin drug. Regardless, the symptoms fade once you stop taking a statin.
Another type of cholesterol-lowering drug -- fibrates -- is discussed next.
For more information on diabetes, and its effect on cholesterol and the heart, try the following links:
- Diabetes and Heart Disease explains the relationship between these two conditions.
- Diabetes Symptoms covers the diverse signs of the disease, from increased thirst and hunger to sudden weight loss.
- To learn more about diabetes in general, including diagnosis, causes, symptoms, and treatment, visit our main Diabetes page.
- For more information on cholesterol and its effect on your health, read How Cholesterol Works.
This information is solely for informational purposes. IT IS NOT INTENDED TO PROVIDE MEDICAL ADVICE. Neither the Editors of Consumer Guide (R), Publications International, Ltd., the author nor publisher take responsibility for any possible consequences from any treatment, procedure, exercise, dietary modification, action or application of medication which results from reading or following the information contained in this information. The publication of this information does not constitute the practice of medicine, and this information does not replace the advice of your physician or other health care provider. Before undertaking any course of treatment, the reader must seek the advice of their physician or other health care provider.
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Please copy/paste the following text to properly cite this How Stuff Works article:
Gower, Timothy. "Diabetes and Cholesterol Medications." 05 March 2007. HowStuffWorks.com. <http://health.howstuffworks.com/diabetes-and-cholesterol-medications.htm> 17 May 2008.
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Abdominal Bloating Abdominal Fullness Prematurely Afte... Abdominal Lumps Abdominal Mass Abdominal Pain Abdominal Rigidity Abdominal Sounds Abdominal Swelling Abnormal Posturing Abnormal Tooth Shape Abnormally Dark Or Light Skin Absent Menstruation Absent Thirst Agitation Ambiguous Genitalia Ankle Pain Appetite Decrease Appetite Increase Apraxia Arachnodactyly Armpit Lump Autistic Behavior Babinski's Reflex Bed Wetting Belching Binge Eating Blackheads Bleeding Gums Bleeding Into The Skin Blindness Blockage Of Leg Arteries Blood In The Semen Blood in Urine Bloody Or Tarry Stools Bone Pain Or Tenderness Bounding Pulse Bowel Incontinence Breast Lump Breast Pain Breath Odor Breath Sounds Breathing - Slowed Or Stopped Breathing Difficulty Breathing Difficulty When Lying Dow... Breathing That Sounds Abnormal Broad Nasal Bridge Bulging Fontanelles Bullae Chemosis Chest Pain Chills Clammy Skin Claw Foot Claw Hand Cloudy Cornea Clubbing Of The Fingers Or Toes Cold Intolerance Coloboma Of The Iris Comedones Confusion Constipation Contracture Deformity Coughing Coughing Up Blood Crying Excessively in Infants Cyst Decerebrate Posture Decorticate Posture Decreased Consciousness Decreased Urine Output Delayed Growth Delayed or Absent Tooth Formation Depression Diarrhea Difficulty with Urination Dizziness Drooling Drowsiness Dry Eyes Dry Hair Dry Skin Ear Discharge Earache Earlobe Creases Elbow Pain Epicanthal Folds Erection Problems Erosion Excessive Or Unwanted Hair In Women Excessive Thirst Excessive Urination Excessive Urination at Night Excessively Large Fontanelles Eye Burning, Itching and Discharge Eye Pain Eye Redness Eye Slant Eyelid Drooping Eyes That Bulge Face Pain Facial Paralysis Facial Swelling Fainting Fatigue Female Sexual Dysfunction Fever Finger Pain Fingers That Change Color Flank Pain Floating Stools Focal Neurological Deficits Foot Pain Foot, Leg, And Ankle Swelling Foul Smelling Stools Frequent Or Urgent Urination Frontal Bossing Gas (Flatulence) Gastrointestinal Bleeding Genital Sores (Female) Genital Sores (Male) Groin Lumps Groin Pain Gynecomastia Hair Loss Hallucinations Hand Or Foot Spasms Hand Tremors Headache Hearing Loss Heart Murmurs And Other Sounds Heart Palpitations Heartburn Heat Intolerance Heavy, Prolonged, or Irregular Mens... Heel Pain Hemolytic Crisis Hepatomegaly Heterochromia Hiccups Hip Pain Hoarseness Or Changing Voice Hump Behind The Shoulders Hyperactivity Hyperelastic Skin Hypermobile Joints Hyperventilation Hypotonia Impaired Smell Increased Head Circumference Indigestion Infantile Reflexes Intercostal Retractions Intertrigo Irritability Itching Jaundice (Yellow Skin) Joint Pain Joint Swelling Knee Pain Leg Pain Lichenified Limited Range Of Motion Lordosis Low Nasal Bridge Lower Back Pain Macule Malaise Memory Loss Metopic Ridge Microcephaly Micrognathia Morbid Obesity Morning Sickness Moro Reflex Motormental Retardation Mouth Sores Muscle Aches Muscle Atrophy Muscle Cramps Muscle Function Loss Muscle Twitching Nail Abnormalities Nasal Congestion Nasal Discharge Nasal Flaring Natal Teeth Nausea And Vomiting Neck Lumps Neck Pain Night Blindness Nightmares Nikolsky’s Sign Nipple Discharge Nodules Nosebleed Numbness And Tingling Obesity Opisthotonos Pain During Sexual Intercourse Painful Menstrual Periods Painful Urination Pale or Clay-Colored Stools Paleness Papule Patches Patchy Skin Color Pectus Carinatum Pectus Excavatum Penis Pain Photophobia Pilonidal Dimple Pinna Abnormalities And Low-set Ear... Point Tenderness Polydactyly Polyhydramnios Poor Feeding In Infants Preauricular Tag Or Pit Premenstrual Breast Tenderness and ... Prognathism Pupils That Are Different Sizes Purpura Pustules Rapid Shallow Breathing Rash in a Child Under 2 Years Rashes Rib Cage Pain Ridged Sutures Scales Scrotal Swelling Seizures Sensorineural Deafness Separated Sutures Shin Splints Short Philtrum Short Stature Shoulder Pain Simian Crease Skeletal Limb Abnormalities Skin Blushing/flushing Skin Discoloration Skin Lumps Skin Turgor Sleeping Difficulty Sneezing Snoring Sore Throat Spasticity Speech Impairment (adult) Splenomegaly Splinter Hemorrhages Strange Behavior Stress And Anxiety Striae Subcutaneous Emphysema Sunburn Sunken Fontanelles Supernumerary Nipples Swallowing Difficulty Swallowing Pain Or Burning Sweating Sweating Decrease Swelling Swollen Glands Swollen Gums Taste Impairment Telangiectasia Tenesmus Testicle Lump Testicle Pain Tinnitus Tongue Problems Tooth Discoloration Toothaches Ulcers Uncontrollable Eye Movements Uncontrollable Movement Uncontrolled Or Slow Movement Uncoordinated Movement Unpredictable Or Jerky Movement Urinary Incontinence Urine Discoloration Vaginal Bleeding Between Periods Vaginal Bleeding In Pregnancy Vaginal Discharge Vaginal Itching Vesicles Vision Problems Vomiting Blood Walking Abnormalities Watery Eyes Weak or Absent Pulse Weakness Webbing Of The Fingers Or Toes Weight Gain Weight Loss Wheezing White Spots in the Pupil Whitehead Widely Spaced Teeth Wrinkles Wrist Pain Yawning
DISEASES AND CONDITIONS GLOSSARY:
Aarskog Syndrome Aase Syndrome Abdominal Aortic Aneurysm ABO Incompatibility Abortion - Complete Abortion - Elective Or Therapeutic Abortion - Incomplete Abortion - Infected Abortion - Threatened Abscess Acanthosis Nigricans Achalasia Achilles Tendinitis Achondrogenesis Achondroplasia Acidosis Acne Acoustic Neuroma Acoustic Trauma Acquired Platelet Function Defect Acrodermatitis Acrodysostosis Acromegaly Actinic Keratosis Actinomycosis Acute Adrenal Crisis Acute Arterial Occlusion - Kidney Acute Bilateral Obstructive Uropath... Acute Bronchitis Acute Cerebellar Ataxia Acute Cholecystitis (Gallstones) Acute Cytomegalovirus (CMV) Infecti... Acute Gouty Arthritis Acute HIV Infection Acute Interstitial Nephritis Not NS... Acute Kidney Failure Acute Lymphocytic Leukemia (ALL) Acute Mountain Sickness Acute Myeloid Leukemia Acute Nephritic Syndrome Acute Pancreatitis Acute Tubular Necrosis Acute Unilateral Obstructive Uropat... Acute Upper Airway Obstruction Addison’s Disease Adenomyosis Adhesion Adjustment Disorder Adolescent Depression Adolescent Pregnancy Adrenocortical Carcinoma Adrenoleukodystrophy Adult Still's Disease Agammaglobulinemia Age-related Hearing Loss Agoraphobia Agranulocytosis Aicardi Syndrome AIDS Albinism Alcohol Withdrawal Alcoholic Cardiomyopathy Alcoholic Ketoacidosis Alcoholic Liver Disease Alcoholic Neuropathy Alcoholism Alkalosis Alkaptonuria Allergic Conjunctivitis Allergic Rhinitis Allergic Vasculitis Allergies Allergy To Mold - Dander - Dust Alopecia Areata Alpha-1 Antitrypsin Deficiency Alport Syndrome Alström Syndrome Alveolar Abnormalities Alzheimer’s Disease Amaurosis Fugax Amblyopia Amebiasis Amebic Liver Abscess Amelogenesis Imperfecta Amenorrhea Amniotic Constriction Bands Amphetamine Or Sympathomimetic Into... Amyotrophic Lateral Sclerosis Anal Fissure Analgesic Nephropathy Anaphylaxis Anaplastic Thyroid Cancer Androgen Insensitivity Syndrome Anemia Anemia - B12 Deficiency Anemia Of Chronic Disease Anencephaly Aneurysm Aneurysm In The Brain Angina Angiodysplasia Of The Colon Angioedema Ankylosing Spondylitis Annular Pancreas Anorchia Anorectal Abscess Anorexia Nervosa Anthrax Antisocial Personality Disorder Aortic Arch Syndrome Aortic Dissection Aortic Insufficiency Aortic Stenosis Apert Syndrome Apnea Of Prematurity Apoplexy Appendicitis ARDS (acute Respiratory Distress Sy... Arrhenoblastoma of the Ovary Arrhythmias Arterial Embolism Arterial Insufficiency Arteriosclerosis Of The Extremities Arteriovenous Malformation - Cerebr... Arthritis Asbestos-related Pleural Effusion Asbestosis Ascariasis Ascites Aseptic Meningitis Aseptic Necrosis Asherman Syndrome Asperger Syndrome Aspergillosis Aspiration Pneumonia Asthma Astigmatism Asymptomatic Bacteriuria Asymptomatic HIV Infection Ataxia-telangiectasia Atelectasis Atheroembolic Renal Disease Atherosclerosis Athlete's Foot Atrial Fibrillation/flutter Atrial Myxoma Atrial Septal Defect Atrophic Vaginitis Attention Deficit Hyperactivity Dis... Atypical Mycobacterial Infection Atypical Pneumonia Aural Polyps Autism Autoerythrocyte Sensitivity Autoimmune Disorders Autoimmune Hepatitis Autonomic Hyperreflexia Autonomic Neuropathy Avian Influenza Avoidant Personality Disorder Axillary Nerve Dysfunction Bacterial Gastroenteritis Baker’s Cyst Balanitis Barbiturate Intoxication And Overdo... Barrett’s Esophagus Bartholin’s Abscess Bartter Syndrome Basal Cell Carcinoma Basal Cell Nevus Syndrome Basal Ganglia Dysfunction Bassen-Kornzweig Syndrome Bathing Trunk Nevus Becker's Muscular Dystrophy Beckwith-Wiedemann Syndrome Bedwetting Bell's Palsy Benign Ear Cyst Or Tumor Benign Positional Vertigo Beriberi Bezoar Bilateral Hydronephrosis Bile Duct Obstruction Biliary Atresia Biliary Stricture Bipolar Disorder Birth-acquired Herpes Birthmarks - Pigmented Birthmarks - Red Bladder Cancer Bladder Outlet Obstruction Bladder Stones Blastomycosis Blastomycosis Skin Lesion Bleeding Disorders Bleeding Esophageal Varices Blepharitis Blind Loop Syndrome Blocked Tear Duct Blood Clots Blount's Disease Body Lice Bone Tumors Borderline Personality Disorder Botulism Bowlegs Brachial Palsy In Newborns Brachial Plexopathy Brain Abscess Brain Herniation Brain Tumor - Adults Brain Tumor - Children Branchial Cleft Cyst Breast Cancer Breast Infection Breast Milk Jaundice Breath Holding Spell Brief Reactive Psychosis Bronchial Adenoma Bronchiectasis Bronchiolitis Bronchitis Bronchopulmonary Dysplasia Brucellosis Bruxism Bulimia Bullous Pemphigoid Bunions Burkitt Lymphoma Bursitis Byssinosis Campylobacter Enteritis Canavan Disease Cancer Cancer - Penis Cancer - Renal Pelvis Or Ureter Cancer - Throat Or Larynx Cancer - Vulva Candida Esophagitis Canker Sores Caplan Syndrome Caput Succedaneum Carbunculosis Carcinoid Syndrome