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What should I know about methysergide?

        Health | Headache

Methysergide is used to prevent migraines or to reduce their frequency and intensity for people who have them more than once a week. Your doctor may also prescribe this medication if your pain is very severe, regardless of how often you have headaches. This medication is not used to reduce the pain of a headache.

How does methysergide work?

Methysergide changes the level of serotonin in the brain. Serotonin is a chemical in your brain that may play a role in the occurrence of vascular headaches.

What are the possible side effects of using methysergide and what should I do about them?

The following side effects are generally not considered serious. You still, though, should let your doctor know if you experience any of the following:

  • body pains
  • diarrhea
  • dizziness
  • drowsiness
  • facial flush
  • heartburn
  • insomnia
  • nausea
  • vomiting
  • weakness

The following are serious side effects. You will need to work closely with your doctor if you experience any of these:

  • blood pressure that's too low, called hypotension
  • a narrowing of your blood vessels, called vasoconstriction
  • a rapid heartbeat
  • edema, or swelling
  • a white blood cell deficiency
  • cardiovascular problems

What are the possible drug interactions with methysergide?

Methysergide can have an adverse effect if taken with beta-blockers. For instance, a cold feeling in your hands and feet is a sign that not enough blood is getting to your capillaries. Let your doctor know if this begins to happen.

Always talk with your doctor and pharmacist about possible drug interactions with any new medication you take. Tell your doctor and pharmacist about all the other medications you are taking. You should also tell them about your other medical conditions, both past and present. You need to keep your regular appointments while you take this medication so that your doctor can keep track of your progress.


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