![]() Photo courtesy CSIRO In this electron micrograph, you can see neuraminidase "spikes" surrounding the influenza virus. |
There are, however, a few approved antiviral drugs, including Symmetrel®, Flumadine®, Relenza® and Tamiflu®, that have been shown to shorten the duration of the illness.
Relenza® (zanamivir) and Tamiflu® (oseltamivir phosphate) are neuraminidase inhibitors. They work by blocking the action of a protein called neuraminidase, which sits on the surface of a cell and normally helps the influenza virus enter and leave the cell. Neuraminidase inhibitors trap the virus once it enters a cell.
![]() Photo courtesy CSIRO Health Sciences and Nutrition Relenza® (zanamivir) releases beads that bind to neuraminidase proteins, stopping the virus from leaving the infected cell and spreading to others. |
By stopping the virus from spreading to other cells, Relenza® and Tamiflu® lessen the severity and shorten the duration of the flu infection.
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Left: Relenza® powder-filled capsules and inhaler device; Right: Relenza® beads in an active neuraminidase pocket | |
Symmetrel® and Flumadine® also lessen the severity and shorten the duration of the flu, but they only work against influenza A. Both are antiviral medications that work by stopping the virus from replicating.
All four drugs are by prescription only and do have potential side effects, so they should only be taken with the advice of a doctor.
The best advice for treating the flu is to rest and drink plenty of liquids. Over-the-counter cold and flu remedies can alleviate some of the symptoms, at least temporarily. Aspirin may relieve fever and aches, but it should not be given to children and adolescents because of the risk of a rare but potentially dangerous illness called Reye's Syndrome.
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