Make HowStuffWorks your homepage
Search HowStuffWorks and the web:
Please copy/paste the following text to properly cite this How Stuff Works article:
Ferguson, Jill. "How Inotropic Drugs Work." 17 March 2008. HowStuffWorks.com. <http://health.howstuffworks.com/inotropic-drug.htm> 17 May 2008.
Inside This Article
Positive Inotropic Drugs
Positive inotropic drugs improve heart function in cases of heart failure (when the heart is not pumping well enough), heart attacks and various types of heart disease. They can be divided into four types based on how they work:
-
Beta-agonists
-
Digitalis compounds
-
Phosphodiesterase inhibitors
-
Calcium-sensitizing drugs
Doctors very often prescribe one of the digitalis compounds, digoxin, for patients with heart failure. It increases the force of muscular contractions in the failing heart. Studies have shown that digoxin can improve the symptoms of heart failure in patients who are already taking diuretics (drugs that help rid the body of excess sodium salt and water) and ACE inhibitors, a type of vasodilator drug that helps widen blood vessels.
Apart from digoxin, other positive inotropic drugs should be used only for acute or end-stage heart failure because their prolonged use has been shown to worsen the disease outcome, and they may even increase the risk of death in some heart failure patients. These drugs can have a short-term benefit for some patients, but they may be harmful with long-term use.
Some positive inotropic drugs are given in pill form, and some are given intravenously (through a needle into a vein, usually in the arm). Patients who haven't responded to other treatments may be given intravenous positive inotropic drugs every so often on a regular basis. This is called intermittent therapy. It's a good idea for patients taking an intravenous positive inotropic drug to try stopping the drug every six months to see if they still need it.
PREVIOUS
Inside This Article
More Options:
Please copy/paste the following text to properly cite this How Stuff Works article:
Ferguson, Jill. "How Inotropic Drugs Work." 17 March 2008. HowStuffWorks.com. <http://health.howstuffworks.com/inotropic-drug.htm> 17 May 2008.
ADVERTISEMENT
SYMPTOM CHECKER:
Abdominal Bloating Abdominal Fullness Prematurely Afte... Abdominal Lumps Abdominal Mass Abdominal Pain Abdominal Rigidity Abdominal Sounds Abdominal Swelling Abnormal Posturing Abnormal Tooth Shape Abnormally Dark Or Light Skin Absent Menstruation Absent Thirst Agitation Ambiguous Genitalia Ankle Pain Appetite Decrease Appetite Increase Apraxia Arachnodactyly Armpit Lump Autistic Behavior Babinski's Reflex Bed Wetting Belching Binge Eating Blackheads Bleeding Gums Bleeding Into The Skin Blindness Blockage Of Leg Arteries Blood In The Semen Blood in Urine Bloody Or Tarry Stools Bone Pain Or Tenderness Bounding Pulse Bowel Incontinence Breast Lump Breast Pain Breath Odor Breath Sounds Breathing - Slowed Or Stopped Breathing Difficulty Breathing Difficulty When Lying Dow... Breathing That Sounds Abnormal Broad Nasal Bridge Bulging Fontanelles Bullae Chemosis Chest Pain Chills Clammy Skin Claw Foot Claw Hand Cloudy Cornea Clubbing Of The Fingers Or Toes Cold Intolerance Coloboma Of The Iris Comedones Confusion Constipation Contracture Deformity Coughing Coughing Up Blood Crying Excessively in Infants Cyst Decerebrate Posture Decorticate Posture Decreased Consciousness Decreased Urine Output Delayed Growth Delayed or Absent Tooth Formation Depression Diarrhea Difficulty with Urination Dizziness Drooling Drowsiness Dry Eyes Dry Hair Dry Skin Ear Discharge Earache Earlobe Creases Elbow Pain Epicanthal Folds Erection Problems Erosion Excessive Or Unwanted Hair In Women Excessive Thirst Excessive Urination Excessive Urination at Night Excessively Large Fontanelles Eye Burning, Itching and Discharge Eye Pain Eye Redness Eye Slant Eyelid Drooping Eyes That Bulge Face Pain Facial Paralysis Facial Swelling Fainting Fatigue Female Sexual Dysfunction Fever Finger Pain Fingers That Change Color Flank Pain Floating Stools Focal Neurological Deficits Foot Pain Foot, Leg, And Ankle Swelling Foul Smelling Stools Frequent Or Urgent Urination Frontal Bossing Gas (Flatulence) Gastrointestinal Bleeding Genital Sores (Female) Genital Sores (Male) Groin Lumps Groin Pain Gynecomastia Hair Loss Hallucinations Hand Or Foot Spasms Hand Tremors Headache Hearing Loss Heart Murmurs And Other Sounds Heart Palpitations Heartburn Heat Intolerance Heavy, Prolonged, or Irregular Mens... Heel Pain Hemolytic Crisis Hepatomegaly Heterochromia Hiccups Hip Pain Hoarseness Or Changing Voice Hump Behind The Shoulders Hyperactivity Hyperelastic Skin Hypermobile Joints Hyperventilation Hypotonia Impaired Smell Increased Head Circumference Indigestion Infantile Reflexes Intercostal Retractions Intertrigo Irritability Itching Jaundice (Yellow Skin) Joint Pain Joint Swelling Knee Pain Leg Pain Lichenified Limited Range Of Motion Lordosis Low Nasal Bridge Lower Back Pain Macule Malaise Memory Loss Metopic Ridge Microcephaly Micrognathia Morbid Obesity Morning Sickness Moro Reflex Motormental Retardation Mouth Sores Muscle Aches Muscle Atrophy Muscle Cramps Muscle Function Loss Muscle Twitching Nail Abnormalities Nasal Congestion Nasal Discharge Nasal Flaring Natal Teeth Nausea And Vomiting Neck Lumps Neck Pain Night Blindness Nightmares Nikolsky’s Sign Nipple Discharge Nodules Nosebleed Numbness And Tingling Obesity Opisthotonos Pain During Sexual Intercourse Painful Menstrual Periods Painful Urination Pale or Clay-Colored Stools Paleness Papule Patches Patchy Skin Color Pectus Carinatum Pectus Excavatum Penis Pain Photophobia Pilonidal Dimple Pinna Abnormalities And Low-set Ear... Point Tenderness Polydactyly Polyhydramnios Poor Feeding In Infants Preauricular Tag Or Pit Premenstrual Breast Tenderness and ... Prognathism Pupils That Are Different Sizes Purpura Pustules Rapid Shallow Breathing Rash in a Child Under 2 Years Rashes Rib Cage Pain Ridged Sutures Scales Scrotal Swelling Seizures Sensorineural Deafness Separated Sutures Shin Splints Short Philtrum Short Stature Shoulder Pain Simian Crease Skeletal Limb Abnormalities Skin Blushing/flushing Skin Discoloration Skin Lumps Skin Turgor Sleeping Difficulty Sneezing Snoring Sore Throat Spasticity Speech Impairment (adult) Splenomegaly Splinter Hemorrhages Strange Behavior Stress And Anxiety Striae Subcutaneous Emphysema Sunburn Sunken Fontanelles Supernumerary Nipples Swallowing Difficulty Swallowing Pain Or Burning Sweating Sweating Decrease Swelling Swollen Glands Swollen Gums Taste Impairment Telangiectasia Tenesmus Testicle Lump Testicle Pain Tinnitus Tongue Problems Tooth Discoloration Toothaches Ulcers Uncontrollable Eye Movements Uncontrollable Movement Uncontrolled Or Slow Movement Uncoordinated Movement Unpredictable Or Jerky Movement Urinary Incontinence Urine Discoloration Vaginal Bleeding Between Periods Vaginal Bleeding In Pregnancy Vaginal Discharge Vaginal Itching Vesicles Vision Problems Vomiting Blood Walking Abnormalities Watery Eyes Weak or Absent Pulse Weakness Webbing Of The Fingers Or Toes Weight Gain Weight Loss Wheezing White Spots in the Pupil Whitehead Widely Spaced Teeth Wrinkles Wrist Pain Yawning