The most common side effect of Cymbalta is mild to moderate nausea, which usually abates in one to three weeks. Other common side effects include dry mouth, insomnia, constipation, heartburn, sweating, increased urination or difficulty urinating, drowsiness, decreased appetite and dizziness. Cymbalta may cause sexual dysfunction in men but does so to a lesser extent in women.
As with many antidepressants, Cymbalta can increase thoughts of suicide when it's first taken, particularly in young adults. When first taking Cymbalta, you should alert a health care provider immediately if you have dramatic changes in mood or behavior, including thoughts of suicide.
You should, of course, tell your doctor about any other medications you're taking. If you're on MAOIs or thioridazine, for example, you shouldn't be taking Cymbalta. The drug can also make glaucoma worse, so if you've got the condition, you'll want to try something else instead.
Some of the more severe side effects of Cymbalta are indications that it's having an adverse effect on your liver, including pain in the right upper belly area, darkened urine or yellow skin and eyes.
You may also experience side effects when you stop taking the drug, including nausea, headache and dizziness.
For more information on Cymbalta and other popular prescription drugs, see the stories on the next page.