Like HowStuffWorks on Facebook!

Tricyclic Antidepressants (TCAs)

Drug Reactions & Precautions

Possible Drug Interactions With TCAs

To help you avoid unnecessary side effects, use caution when taking TCAs with other drugs. Tell your doctor about all other drugs you are taking - it's even a good idea to let your doctor see your other prescription containers. Not all drugs in the categories listed below will react with TCAs - your doctor is the best judge.

Drugs to Avoid When You Take a TCA

Before you start taking a TCA drug, make sure you tell your doctor if you take any drugs from this list.

  • alcohol
  • antibiotics
  • antidepressants (others)
  • antihistamines
  • antipsychotics
  • asthma medications
  • barbiturates
  • blood-clotting drugs
  • drugs for heart arrythmias
  • drugs for tremors
  • high blood pressure drugs
  • monoamine oxidase inhibitors
  • rifamycins (for tuberculosis)
  • seizure drugs
  • SSRIs
  • thyroid hormone
  • tobacco
  • ulcer drugs
  • valproic acid
  • 1
  • 2