If you don't want to take a hormone like the birth control pill, spironolactone (brand name: Aldactone) has also been used to treat hormonal acne breakouts. This drug has an effect on the hair follicle and starves the bacteria that cause acne, says Dr. Buka. Possible side effect include raised potassium levels, decreased blood pressure, irregular menstrual cycles and breast tenderness. Because it is a diuretic, users should be careful when exercising in hot weather. Research shows it to be safe for long-term use, and Dr. Buka says very rarely a patient will say they're experiencing headaches from this medication.