It's really important to keep the skin around the diaper area clean to prevent bacteria from spreading. At every changing you should clean the skin with warm water and either a soft cloth or cotton balls. A soft washcloth or even a flannel cloth works well. Don't use soap, though, unless the area is really dirty. Even then, make sure the soap you use is mild.
Also, take a look at the type of baby wipe you're using. To avoid burning the skin and spreading bacteria, don't use wipes that contain alcohol or propylene glycol, especially if a rash is present. Fragrances in wipes can irritate a baby's skin, too.
After washing your baby's skin, be sure to dry it thoroughly. Use a clean towel and always pat the skin dry. Rubbing it can cause irritations. Finally, wash your hands after every diaper change so you don't spread any bacteria.
Drying your baby after a diaper change is just one way to keep him dry. Read on for other drying tips.