Just as high cholesterol can affect a man's erection, it can also affect a woman's ability to get aroused. It's no news to a woman that carrying a few extra pounds can make you less inclined to take off all of your clothes in front of another person. But it's not just insecurity that may be driving such a feeling. Extra weight raises your cholesterol count, and just as it does for guys, cholesterol can build up in your arteries and make it difficult for blood to reach your pelvic region. That makes it hard for a woman to get aroused and lubricated prior to sexual intercourse, and there's nothing like painful sex to get you out of the mood. Using a lubricant won't completely solve a woman's sexual problems, either. Some of those clogged arteries lead to the clitoris, making an orgasm or any kind of pleasurable sensation almost impossible. Again, check with your doctor to be sure that cholesterol, and not some other underlying medical condition, is to blame.