Bile Acid Resins to Lower Cholesterol

Possible Drug Interactions With Bile Acid Resins

Bile acid resins may interact with or decrease absorption of these:

  • antibiotics
  • blood thinners
  • the cholesterol medicines gemfibrozil, clofibrate, and nicotinic acid
  • diabetes medicines
  • gallstone medicines
  • nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen
  • seizure medicines
  • steroid medicines
  • thyroid hormones
  • vitamins A, D, E, and K
Ask your pharmacist for a complete list of possible interactions.

Also, work closely with your doctor or pharmacist to develop a schedule for taking your medicines. You need to separate your bile acid resins from other drugs that may interact. The usual guideline is to take other medicines at least 1 hour before or 4 to 6 hours after you take a bile acid resin. If you follow a schedule like this, you can decrease the risk of adverse reactions. Since this can make your medicine regimen more complicated, work with your healthcare team. Also, use your medicine diary to help keep all your medicines working together safely.