What's aortic valve disease?

Causes and Effects of Aortic Valve Disease
You can see the three leaflets on this closed tricuspid valve.
You can see the three leaflets on this closed tricuspid valve. Images

Your aortic valve normally has three snugly fitting, triangular leaflets (sometimes called cusps or flaps) attached to a ring of tissue called the annulus. Aortic valve disease occurs when stenosis, regurgitation or, in really unlucky people, both cause the aortic valve not to work properly.

Stenosis happens when you have a narrowed or hardened valve that restricts the amount of blood passing through it. Regurgitation occurs when blood leaks back into the ventricle through poorly sealing leaflets. In either scenario, your heart must pump harder to push the proper amount of blood through the faulty passage. As a result of the extra effort, either the heart tissue gets thicker (hypertrophic cardiomyopathy) or the left ventricle becomes larger (dilated cardiomyopathy), ultimately reducing your heart's performance. Your aortic valve isn't the only one that can be diagnosed with stenosis or regurgitation, but it's the one that matters in aortic valve disease.

­What causes this aortic sentry to go awry? Calcium, for one. As we get older, it accumulates on the aortic valve, and this is a primary cause of stenosis [source: Nishimura]. These deposits stiffen the leaflets, thicken the annulus and commonly appear around age 60, but they don't necessarily have anything to do with your calcium intake [source: Mayo]. An aortic valve that started off too narrow from birth also can lead to stenosis (called congenital aortic valve disease). Regurgitation, on the other hand, may stem from good old-fashioned wear and tear, problems with the aorta itself and rheumatic fever (also a cause of stenosis).

If your aortic valve is damaged, your body may alert you in a variety of ways. You may feel dizzy, suffer chest pains or see swelling in your feet. Early on, you may notice you're especially winded during exercise. As the condition progresses, shortness of breath can occur when you're resting or even sleeping. A heart murmur may also develop, and this telltale sign often alerts doctors to the condition during routine checkups.

­Without serious symptoms, aortic valve disease may simply require an easygoing lifestyle -- due to the heart's limited ability to deliver oxygenated blood -- and regular cardiology exams. Sometimes, doctors can open a stenotic valve by inserting a catheter with a tiny balloon into the body, pushing it through a vein to the aortic valve and then expanding the balloon, knocking the leaflets fully apart. Other times, surgeons reshape leaflets to prevent regurgitation. However, if symptoms worsen, your faulty aortic valve may need to be replaced with a mechanical or biological one during open-heart surgery [source: Nishimura].

After a successful transplant, patients are usually as good as they ever were, or even better [source: Sundt]. If you have aortic valve disease and need a transplant, console yourself in knowing that, after the procedure, you'll likely be living a long, happy life as you motor on down the road with a top-notch replacement valve in your tuned-up engine.

See the next page for many more stories about that hardworking engine of yours.

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