People with type 2 diabetes have less sensitive insulin receptors in the cell membranes. Insulin must attach to a receptor in order for glucose to be able to leave the blood and enter the cell. Less-sensitive receptors mean insulin can't bind. And that means glucose can't get into the cell. The result is twofold. The level of glucose in the blood stays high, and the cells don't have the energy they need from glucose. Thiazolidinediones work by increasing the sensitivity of the insulin receptor sites in muscle, fat and liver cells. This allows more of the body's own insulin to bind with receptors. And that allows glucose to pass from the blood and into the body's cells. Since glucose can get into the cells, it can be used for energy. This type of diabetes pill also decreases the liver's production of glucose. Both of these actions work together to decrease the amount of glucose in the blood.