Promotility Agents

Promotility agents, such as Reglan, help reduce symptoms of GERD and speed healing of the esophagus. Because they must be taken several times a day, your doctor will decide if this is the best treatment for you.

How Promotility Agents Work

Promotility agents work by helping the stomach contents move to the small intestine more quickly, thus giving acid in the stomach less time to reflux. They also work by increasing the tightness or pressure of the lower esophageal sphincter, so it can work properly.


Possible Side Effects of Promotility Agents

If you experience any side effects while taking Reglan, speak with your doctor. In some people, Reglan may cause:

  • agitation
  • anxiety
  • arrhythmias
  • blood pressure changes
  • diarrhea
  • drowsiness
  • hormone imbalances
  • insomnia
  • involuntary muscle movements
  • reduced white blood cell counts
  • restlessness
  • seizures
  • unusual fatigue
  • urinary incontinence
  • visual disturbances

Less Common Side Effects

Less common side effects from promotility agents include:

  • breast tenderness
  • constipation
  • dizziness
  • dry mouth
  • headache

Possible Drug Interactions with Promotility Agents

To help you avoid unnecessary side effects, use caution when taking promotility agents with other drugs. Tell your doctor about all other drugs you are taking - it's a good idea to let your doctor see your other prescription containers.

Drugs to Avoid with Promotility Agents

Before you start taking a promotility agent, tell your doctor if you use any of these drugs:

  • alcohol
  • heart medications
  • drugs for Parkinson's disease
  • antidepressants (MAO inhibitors)
  • ulcer medications
  • pain medications
  • drugs for bladder problems
  • drugs given with general anesthesia

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