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What should I know about tricyclic antidepressants?

Drug Interactions

What are the possible drug interactions with tricyclic antidepressants?

To help you avoid unnecessary side effects, use caution when taking these medications with other drugs. Tell your doctor about all other drugs you are taking. It's even a good idea to let your doctor see your other prescription containers.

Below is a partial list of drugs that can cause unwanted effects if taken with tricyclic antidepressants. Your doctor can help you know whether or not you can safely take tricyclic antidepressants with the other medications you take.

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Other Antidepressants

  • Prozac (fluoxetine HCl)
  • Luvox (fluvoxamine maleate)
  • Paxil (paroxetine HCl)
  • Zoloft (sertraline HCl)
  • monoamine oxidase inhibitors

Heart Medications Used for Rhythm Abnormalities

  • Tambocor (flecainide acetate)
  • Rythmol (propafenone HCl)

Sedating Medications Such as Barbiturates

  • Luminal Sodium (phenobarbital)
  • Seconal Sodium (secobarbital sodium)
  • Amytal (amobarbital sodium)

Anticholinergic Medications

  • Bentyl (dicyclomine HCl)
  • Ditropan (oxybutynin)

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