10 Off-label Uses of Antidepressants

Delaying Premature Ejaculation
When PE is a long-term problem, SSRIs may prove an effective treatment. © dolgachov/iStockphoto

Premature ejaculation (PE) is a problem with sexual performance, and it affects 30 to 70 percent of men age 40 and younger, making it the most common sexual disorder among that age group [source: Deem].

Symptoms of PE include ejaculation within 60 seconds after penetration and ejaculating earlier than he or his partner wants or expects. Symptoms lasting six months or more are diagnosed as PE. While it's a physical symptom, PE is actually considered a psychological problem rather than a physical one. Chronic sufferers may also suffer from depression or anxiety.

Common therapies for treating PE include topical desensitizing agents, but long-term instances may also be treated with a prescription for antidepressants — specifically selective serotonin reuptake inhibitors (SSRIs). SSRIs come with their own set of side effects, two of which are beneficial in this instance: erectile dysfunction and the inability to ejaculate [source: Fallon]. Off-label sertraline (Zoloft), for example, has been found to increase the time to ejaculation in PE sufferers by 7.6 minutes to 16.4 minutes, depending on dosage [source: Stone et al.].