Are we still discovering new antibiotics?


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  • Centers for Disease Control. "Antibiotic Resistance Threats in the United States, 2013." April 23, 2013. (Oct. 16, 2014) http://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threats-2013-508.pdf
  • Cheng, Allen A., Hulming Ding, and Timothy K. Lu. "Enhanced killing of antibiotic-resistant bacteria enabled by massively parallel combinatorial genetics." Proceedings of the National Academy of Sciences of the United States of America, July 14, 2014. (Oct. 16, 2014) http://www.pnas.org/content/111/34/12462.abstract
  • Citorik, Robert, Mark Mimee and Timothy K. Lu. "Sequence-specific microbials using efficiently delivered RNA-guided nucleases." Nature Biotechnology, Sept. 21, 2014. (Oct. 16, 2014) http://www.nature.com/nbt/journal/vaop/ncurrent/nbt.3011/metrics/blogs
  • Krans, Brian. "Two New Classes of Antibiotic Discovered as Drug Resistance Spreads." Healthline, Oct. 12, 2014. (Oct. 16, 2014) http://www.healthline.com/health-news/two-new-antibiotic-classes-discovered-100114#3
  • Nonejuie, Poochit, Michael Burkart, Kit Pogliano, and Joe Pogliano. "Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules." Proceedings of the National Academy of Sciences, September 2013. (Oct. 16, 2014) http://www.pnas.org/content/110/40/16169
  • O'Daniel, Peter I., Zhihong Peng, Hualiang Pi, Sebastian A. Testero, Derong Ding, Edward Spink, Erika Leemans, Marc A. Boudreau, Takao Yamaguchi, Valerie A. Schroeder, William R. Wolter, Leticia I. Llarrull, Wei Song, Elena Lastochkin, Malika Kumarasiri, Nuno T. Antunes, Mana Espahbodi, Katerina Lichtenwalter, Mark A. Suckow, Sergei Vakulenko, Shahriar Mobashery, and Mayland Chang. "Discovery of a New Class of Non-beta-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity." Journal of the American Chemical Society, Feb. 11, 2014. (Oct. 16, 2014) http://pubs.acs.org/doi/abs/10.1021/ja500053x
  • Spellberg, Brad. "New Antibiotic Development: Barriers and Opportunities in 2012." Alliance for the Prudent Use of Antibiotics Newsletter, 2011. (Oct. 16, 2014) http://www.tufts.edu/med/apua/news/news-newsletter-vol-30-no-1-2.shtml
  • Stokes, Jonathan M., Joseph H. Davis, Chand S. Mangat, James R. Williamson, Eric D. Brown. "Discovery of a small molecule that inhibits bacterial ribosome genesis." eLife, Sept. 18, 2014. (Oct. 16, 2014) http://elifesciences.org/content/3/e03574
  • Towse, Adrian, and Priya Sharma. "Incentives for R&D for New Antimicrobial Drugs." Office of Health Economics, April 2011. (Oct. 16, 2014) http://www.ohe.org/publications/article/incentives-for-rd-for-new-antimicrobial-drugs-7.cfm
  • The White House, Office of the Press Secretary. "Executive Order −- Combating Antibiotic-Resistant Bacteria." Sept. 18, 2014. (Oct. 16, 2014) http://www.whitehouse.gov/the-press-office/2014/09/18/executive-order-combating-antibiotic-resistant-bacteria

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