Wouldn't it be great if you could grow a new hand or kidney from your own stem cells, if you needed one? Or maybe replace a few damaged cells with an infusion of new, healthy ones? Or, better yet, get a weakened heart to repair itself?
That's the promise of regenerative medicine, a cutting-edge field that seeks to treat disease and injury by finding novel ways to replace, regenerate and rejuvenate various parts of the human body. Its aim is to fix what ails us through a variety of innovative methods, from transplants to genetic engineering [source: Mayo.edu].
Regenerative medicine is an idea that's been around for a while. Since ancient times, physicians have studied the body's natural ability to heal itself and looked for ways to enhance it [source: UNMC]. In the 1800s, surgeons began successfully grafting donor tissue such as tendons and corneas into patients [source: Conolly and Benanzio]. In the 1950s, they began transplanting kidneys, and a decade later performed the first transplants of lungs, livers, hearts and bone marrow [sources: UNMC, Moore].
In recent years, advances in developmental and cell biology, immunology, genetics and other fields give regenerative medicine the potential to radically change health care. Perhaps the most promising area is experimentation with stem cells, the biological factories that produce the various types of specialized cells that make up our organs [source: Mayo.edu]. In the late 1990s, scientists were able to extract stem cells from human embryos and use them to grow cells in a lab. Not quite a decade later, they figured out how to reprogram adult stem cells so that they could again make many different types of cells [source: NIH].
The first trials for stem cell-based therapies have only recently begun, and it may take years for the treatments to win U.S. Food and Drug Administration approval. But eventually, doctors hope to be able to use stem cells to treat a wide range of diseases, ranging from diabetes and heart disease to spinal cord injuries and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) [source: CIRM].
Researchers at Mount Sinai Medical Center, for example, have used proteins called stem cell factors to repair and regenerate cardiac muscle that was damaged in a heart attack [source: Mount Sinai Medical Center]. And researchers from Harvard University and Boston Children's Hospital have been able to convert skin cells from both mice and humans into pain-sensing neurons [source: Mount Sinai Medical Center]. That raises the possibility that doctors someday may be able to take cells from one of your body parts and convert them into cells for another of your organs, bringing us one step closer to long-term health.
- California Institute for Regenerative Medicine (CIRM). "Turning stem cells into therapies." Cirm.ca.gov. 2013. (Dec. 2, 2014) http://www.cirm.ca.gov/our-progress/stem-cells-therapies
- Conolly, Bruce W. and Benanzio, Mario. "Cosmas and Damian Revisited." Chapter from "Hand Transplantation." Springer. 2007. (Dec. 2, 2014) http://link.springer.com/chapter/10.1007%2F978-88-470-0374-3_1
- Mayo Clinic. "About Regenerative Medicine." Mayo.edu. 2014. (Dec. 2, 2014) http://www.mayo.edu/research/centers-programs/center-regenerative-medicine/patient-care/about-regenerative-medicine
- Moore, Theodore, M.D. "Bone Marrow Transplantation." Medscape. Nov. 7, 2014. (Dec. 2, 2014) http://emedicine.medscape.com/article/1014514-overview
- National Institutes of Health (NIH). "Stem Cell Basics." Nih.gov. (Dec. 2, 2014) http://stemcells.nih.gov/info/basics/pages/basics1.aspx
- Mount Sinai Medical Center. "Delivery of stem cells into heart muscle after heart attack may enhance cardiac repair and reverse injury." ScienceDaily. Nov. 19, 2014. (Dec. 2, 2014) http://www.sciencedaily.com/releases/2014/11/141119174742.htm
- University of Nebraska Medical Center (UNMC). "History of Regenerative Medicine." Hnmc.edu. 2014. (Dec. 2, 2014) http://www.unmc.edu/regenerativemed/history_regenerativemedicine.htm