How Prophylactic Mastectomies Work

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Author's Note: How Prophylactic Mastectomies Work

Angelina Jolie's public discussion of the results of her BRCA genetic testing and subsequent bilateral mastectomy sparked conversation among women and within the medical community because she chose to have surgery before she was diagnosed with cancer. Mastectomy used as a prevention strategy for women who are at high risk for inheriting the disease may save lives, but we can do better in regard to the physical as well as the psychosocial well-being and needs of patients after choosing preventive surgery. It will be interesting to see if the increased public awareness of prophylactic cancer treatments gives a positive boost to not only the awareness of such options but research into new, less invasive treatments.

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  • Aetna. "Clinical Policy Bulletin: BRCA Testing, Prophylactic Mastectomy, and Prophylacctic Oophorectomy." May 14, 2013. (May 24, 2013)
  • Allain, Dawn C., Kevin Sweet, et al. "Management Options After Prophylactic Surgeries in Women With BRCA Mutations: A Review." Cancer Control: Journal of the Moffitt Cancer Center. Vol. 14, no. 4. Pages 330-337. 2007. (May 24, 2013)
  • Balmana, J., O. Diez, et al. "BRCA in Breast Cancer: ESMO Clinical Practice Guidelines." Annals of Oncology. Vol. 22, suppl. 6. Pages vi31-vi34. 2011. (May 24, 2013)
  • "Genetics." May 1, 2013. (May 24, 2013)
  • "Prophylactic Mastectomy." May 16, 2013. (May 24, 2013)
  • "U.S. Breast Cancer Statistics." Oct. 30, 2012. (May 24, 2013)
  • "What Is Mastectomy?" May 16, 2013. (May 24, 2013)
  • Centers for Disease Control and Prevention -- National Program of Cancer Registries (NPCR). "United States Cancer Statistics (USCS)." Jan. 3, 2013. (May 24, 2013)
  • Domchek, Susan. "7 Questions on Cancer Gene Testing." CNN. May 16, 2013. (May 24, 2013)
  • Heemskerk-Gerritsen, B.A.M., Menke-Pluijmers, et al. "Substantial Breast Cancer Risk Reduction and Potential Survival Benefit After Bilateral Mastectomy When Compared With Surveillance in Healthy BRCA1 and BRCA2 Mutation Carriers: A Prospective Analysis." Annals of Oncology. Vol. 24, no. 6. June 2013. (May 24, 2013)
  • National Cancer Institute. "Fact Sheet -- BRCA1 and BRCA2: Cancer Risk and Genetic Testing." May 29, 2009. (May 24, 2013)
  • National Cancer Institute. "Genetics of Breast and Ovarian Cancer (PDQ): Introduction." March 4, 2013. (May 24, 2031)
  • National Cancer Institute. "Preventive Mastectomy." July 27, 2006. (May 24, 2013)
  • Rolnick, Sharon J., Andrea Altschuler, et al.. "What Women Wish They Knew Before Prophylactic Mastectomy." Cancer Nursing. Col. 30, no. 4. Pages 285-291. 2007. (May 24, 2013)
  • Singh, Krishna Jenny Lester, et al. "Impact of Family History on Choosing Risk-reducing Surgery Among BRCA Mutation Carriers." American Journal of Obstetrics and Gynecology. Vol. 208, no. 4. Pages 329.e1-329.e6. April 2013. (May 24, 2013)
  • Szabo, Liz. "'Preventive' Breast Cancer Surgery Has Some Docs Alarmed." USA Today. Oct. 17, 2011. (May 24, 2013)
  • Tuttle, T.M.; A. Abbott, et al. "The Increasing Use of Prophylactic Mastectomy in the Prevention of Breast Cancer." Current Oncology Reports. Vol. 12, no. 1. Pages 16-21. Jan. 2010. (May 24, 2013)