Euphoria Trial Overview


Results of the EUPHORIA Trial

The EUPHORIA trial studied 20 patients with decompensated heart failure (a condition in which the heart is unable to keep the blood circulating well enough) and diuretic resistance. The doctors conducting the study wanted to see whether using ultrafiltration before intravenous diuretic drugs would result in removal of excess fluid and early discharge of patients from the hospital, without the patients' experiencing either low blood pressure or symptoms of worsening kidney disease. The patients were studied while they were hospitalized, and at 30 and 90 days after they were discharged.

An average of more than 8 liters of fluid was removed from the patients by ultrafiltration. Twelve patients were discharged from the hospital within three days of the procedure. Patients had improved symptoms of fluid overload and an average decrease in weight of about 6 kilograms (about 13 pounds) when they were discharged. (They lost weight because excess fluid was removed from their bodies.)

In the three months before the study, 10 hospitalizations occurred in nine patients. After undergoing ultrafiltration, only one patient was readmitted to the hospital in 30 days, and two patients were readmitted between 30 and 90 days for unrelated causes. The patients did not develop either low blood pressure or worsening kidney disease.

The doctors conducting the study also wanted to know whether the patients would feel better earlier in their hospitalization. Using two questionnaires (the Minnesota Living with Heart Failure Questionnaire and the Global Clinical Assessment) to determine how patients felt, they found that patients felt better after ultrafiltration, and at 30 and 90 days.

The doctors who conducted the EUPHORIA study concluded that, in heart failure patients with fluid overload and diuretic resistance, the use of ultrafiltration before the use of intravenous diuretic drugs effectively and safely decreases the length time patients have to be in the hospital and the number of times that they have to be readmitted to the hospital for additional treatment. In addition, the benefits that patients derive from ultrafiltration last at least three months.

To learn more about heart failure and treatments for fluid overload, take a look at the links below.

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Sources

  • Adams KF Jr, Fonarow GC, Emerman CL et al. Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J. 2005;149:209-216.
  • Adams KF, Lindenfeld J, Arnold JMO, et al. Heart Failure Society of America (HFSA) 2006 Comprehensive Heart Failure Practice Guideline. J Cardiac Failure 2006;12:e1-e122.
  • Agostoni P, Marenzi G, Lauri G, et al. Sustained improvement in functional capacity after removal of body fluid with isolated ultrafiltration in chronic cardiac insufficiency: failure of furosemide to provide the same result. Am J Med. 1994;96:191-199.
  • Agostoni P, Marenzi GC, Pepi M, et al. Isolated ultrafiltration in moderate congestive heart failure. J Am Coll Cardiol. 1993;21:424-431.
  • Ahmed A, Young JB, Love TE, et al. A propensity-matched study of the effects of chronic diuretic therapy on mortality and hospitalization in older adults with heart failure. Int J Cardiol. 2007.
  • Bart B, Boyle A, Bank AJ, et al. The RAPID Study: Ultrafiltration versus usual care for hospitalized patients with heart failure: the Relief for Acutely Fluid-Overloaded Patients With Decompensated Congestive Heart Failure. J Am Coll Cardiol. 2005;46:2043-2046.
  • Costanzo MR, Guglin ME, Saltzberg MT, et al. The UNLOAD Study: Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure. J Am Coll Cardiol. 2007; 49:675-683. http://www.unloadstudy.com
  • Costanzo MR, Saltzberg M, O'Sullivan J, et al. The EUPHORIA Study: Early ultrafiltration in patients with decompensated heart failure and diuretic resistance. J Am Coll Cardiol. 2005;46:2047-2051.
  • Elkayam U, Hatamizadeh P, Janmohamed M. The challenge of correcting volume overload in hospitalized patients with decompensated heart failure. J Am Coll Cardiol. 2007;49:684-686.
  • Eshaghian S, Horwich TB, Fonarow GC. Relation of loop diuretic dose to mortality in advanced heart failure. Am J Cardiol. 2006;97:1759-1764.
  • Jaski B, Ha J, Denys BG, et al. The SAFE Study: Peripherally inserted veno-venous ultrafiltration for rapid treatment of volume overloaded patients. J Card Fail. 2003;9:227-231.
  • Marenzi G, Lauri G, Grazi M, et al. Circulatory response to fluid overload removal by extracorporeal ultrafiltration in refractory congestive heart failure. J Am Coll Cardiol. 2001;38:963-968.
  • Mehta RL, Pascual MT, Soroko S, et al. Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA. 2002;288:2547-2553.
  • Pepi M, et al. Sustained cardiac diastolic changes elicited by ultrafiltration in patients with moderate congestive heart failure: pathophysiological correlates. Br Heart J. 1993;70:135-140.

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