Tetracyclic Antidepressants

How Tetracyclics Work

Tetracyclic antidepressants help to maintain higher levels of the chemical messengers norepinephrine and serotonin between sending and receiving neurons in the brain. They do this by slowing reuptake.

Possible Side Effects of Tetracyclic Antidepressants

Not all tetracyclic antidepressants cause side effects. For the types that do, not everyone who takes them will have side effects. Some side effects disappear quickly, and others remain throughout treatment. Elderly patients may be more sensitive to their effects. If you are not sure if your symptoms are from medication, call your doctor.


Bothersome Side Effects

  • agitation
  • anxiety
  • blurred vision
  • confusion
  • constipation
  • dizziness
  • dry mouth
  • fatigue
  • headache
  • sleeping difficulty
  • urination frequency
  • weight gain

More Serious Side Effects

  • glaucoma complications
  • increased cholesterol levels
  • irregular heartbeat
  • lowered blood pressure when standing

Possible Drug Interactions With Tetracyclic Antidepressants

To help avoid unnecessary side effects, use caution when taking other drugs. Tell your doctor about all other drugs you are taking. It's even a good idea to show your doctor your other prescription containers. Not all drugs in the following groups will react with tetracyclic antidepressants - only your doctor will know.

Drugs to Avoid When You Take a Tetracyclic Antidepressant

Before you start taking a tetracyclic antidepressant, make sure you tell your doctor if you are taking any drugs from this list.

  • alcohol
  • antidepressants (other)
  • asthma medications
  • barbiturates
  • blood pressure medications
  • seizure medications
  • thyroid hormones
  • tranquilizers
  • ulcer medications