Does Metformin make you more fertile?

Type 2 diabetes and polycystic ovarian syndrome are often linked with obesity [source: Baby Med]. Approximately 80 percent of Type 2 diabetes patients are either overweight or obese, and more than half of women with PCOS fall into those categories as well [source: Obesity in America.] It's far more difficult, and sometimes impossible, for the human body to maintain a healthy blood sugar level if a person is overweight or obese. Without healthy blood sugar levels, complications begin to arise. The role of Metformin is to establish properly balanced blood sugar and insulin levels [source: Fertility Authority].

Proper blood sugar and insulin levels can help prevent or reduce cysts. When cysts are removed, menstrual cycles tend to become more regular. When menstrual cycles are more predictable, the chances of becoming pregnant increase.

Generally, Metformin is recommended for women with a Body Mass Index above 25 [source: NCCWCH]. There are instances, however, in which Metformin can improve the fertility of women who are neither overweight nor obese. That's because insulin resistance can develop even in people with average or below-average body weight. So, technically speaking, it's the issue of insulin resistance and not necessarily unhealthy body weight that has to be treated to improve the odds of becoming pregnant [source: Elsner]. A change in eating habits alone doesn't always influence fertility.

Metformin can work within days to a few months depending on the woman and her particular medical history. But it's not without its side effects. Some women choose to discontinue use of Metformin because of nausea, diarrhea and other gastrointestinal issues. In rare cases, it can also lead to lactic acidosis -- a serious condition that may be marked by extreme tiredness, a change in skin color or muscular pain [source: WebMD].

Ovulation is not just the process by which an ovary releases an egg; it's marked by the release of a mature egg. An immature ovum causes a cycle that is anovulatory [source: Hernandez-Rey]. Anovulatory cycles or anovulation ensure infertility.

The causes of anovulation can range anywhere from problem with the hypothalamus to the early onset of menopause [source: Stanford]. Polycystic ovarian syndrome is one potential cause [source: Sherbahn]. A woman diagnosed with PCOS can be given various instructions and/or medications by her doctor. Metformin is one such medication. Clomid may be prescribed in conjunction with Metformin to treat PCOS. Once normal insulin levels are seen and menstruation occurs at regular intervals, anovulation may be alleviated [source: Labor of Love]. Those factors increase the chances of a woman becoming pregnant.

Fertility drugs, such as those that hyperstimulate the ovaries, have led to an increase in multiple births [source: Science Daily]. Metformin, however, does not fall into the category of COH (controlled ovarian stimulation) drugs. Since its purpose is to restore insulin production to normal levels and treat PCOS, it has not been linked to an increase in pregnancies involving twins, triplets and other births of more than one child. This fact makes Metformin different than most fertility medications [source: Labor of Love].

Metformin is not an across-the-board treatment for infertility. It has been proven effective in specific cases involving medical issues related to high blood sugar, insulin resistance and polycystic ovarian syndrome. A qualified physician can determine its appropriateness and whether it should be used alone or in combination with other treatments.