Take two aspirin.
Over-the-counter analgesics, such as aspirin and ibuprofen (the ingredient found in Advil and Motrin-IB), are very effective in relieving the pain of shin splints. These medications bring down the swelling and inflammation that may come with these injuries. Acetominophen, the ingredient found in Tylenol and Anacin-3, may ease the pain, but they probably won't do much for inflammation caused by shin splints. Women who are pregnant or nursing a baby, as well as sensitive individuals, should check with their physicians before taking any medications.