Bone Growth, Continued

The Stretching of the Lambs
Baby lambs do about 90 percent of their growing at night, and the same may hold true for growing humans. This may be a primary reason why growing pains are experienced mostly at night by young children [source: BBC].

Before turning into osteocytes, osteoblasts produce cortical bone. One way to imagine this process is to picture a bricklayer trapping himself inside a man-sized brick chamber of his own construction. After forming the hard shell (cortical bone), the bricklayer himself fills the chamber. Air makes its way through the brick and decays the bricklayer. In bone, this part of the process is accomplished by osteoclasts, which make their way into the calcifying cartilage and take bone out of the middle of the shaft, leaving room for marrow to form. Osteoclasts do this by engulfing and digesting the bone matrix using acids and hydrolytic enzymes. So, our bricklayer (osteoblast) made the tomb (cortical bone), died inside the tomb (became an osteocyte), decayed over time (dissolved by osteoclasts) and left behind his remains that formed a network of mass and space inside the brick tomb.

Eventually, all the cartilage has turned to bone, except for the cartilage on the end of the bone (articular cartilage) and growth plates, which connect the bone shaft on each side to the bone ends. These cartilage layers help the bone expand, and finally calcify by adulthood.

So, right now in your body, there are osteoclasts hard at work absorbing old bone cells and osteoblasts helping to build new bone in its place. This cycle is called remodeling. When you're young, your osteoblasts (the builders) are more numerous than the osteoclasts, resulting in bone gain. When you age, the osteoblasts can't keep up with the osteoclasts, which are still efficiently removing bone cells, and this leads to loss of bone mass (and a condition called osteoporosis, which we'll discuss shortly).

What good is making all this bone if you don't get to break some now and then? We'll further explore this line of questioning in the next section.