Diuretics 101

Diuretic Resistance

Advil can decrease the effectiveness of diuretics.
Advil can decrease the effectiveness of diuretics.
James Worrell/Time & Life Pictures/

Up to one in three heart-failure patients who take diuretic drugs experience diuretic resistance: when the process of eliminating excess sodium and water stops before enough fluid has been removed from the patient's body.

In patients with mild heart failure and good kidney function, diuretic resistance is uncommon. However, diuretic resistance occurs more often in patients with moderate or severe heart failure.

What conditions affect the effectiveness of diuretic drugs?

On the next page, we'll learn about how the body's response to diuretics can lead to resistance. We'll also find out how to treat diuretic resistance.