After -- or during -- your shower, rub the bottoms of your feet and heels with a pumice stone to remove dead skin and patchy spots, and follow up with a thick moisturizer. Don't have a pumice stone? Sandpaper will do the trick. A good exfoliation a few times a week -- don't overdo it -- can lessen the need for thick creams to heal calluses, dry heels and soles.
Sound like a lot of effort just for feet? Skip the pumice stone and pick up a foot cream that lists salicylic acid, lactic acid or urea in its ingredients -- these are all known to make skin smoother and are tough enough to handle even the thickest spots on feet in just one step.