The brain's makeup can play a role
To some extent, people who hoard may be hard-wired for the behavior. Studies have revealed marked differences between the functioning of the brain's frontal lobe in hoarders versus non-hoarders. Specifically, the frontal lobe is the critical segment of the brain that, among other things, helps a person think rationally and consider options. So, in a hoarder's frontal lobe, the question of whether or not to throw something away can easily be confounding.