Just like with any supplement or drug, it's important to weigh the benefits with the possible side effects before adding chromium picolinate to your daily regimen. And you should also think about any other medications you currently use. You could check with your physician or pharmacist to find out if there are any possible problems when combining chromium with your other medications. Furthermore, your doctor can give you better, specific information about what kind of side effects you could expect from chromium picolinate.
If you know that you have any allergies to the ingredients in chromium picolinate, it's definitely a good idea to avoid taking the supplements [source: Drugs]. In addition to any allergies, if you know that you're pregnant or nursing or have liver disease, diabetes, cancer or a weakened immune system, you will want to avoid taking chromium picolinate [source: Healthline].
More and more studies are showing that chromium picolinate's negative effects are quite drastic. Two reputable studies have shown that it can trigger mutations in DNA as a result of reactions with other elements found in the body [source: Women Fitness]. These elemental reactions have an adverse effect on DNA, which may cause cancer [source: UC Berkeley Wellness Letter]. Other, less severe reactions may result from the dangerous compounds created from these elements. In addition, since picolinate isn't found naturally occurring with chromium, the picolinate may eventually break apart from the chromium and have negative effects [source: Women Fitness].
It has been noted that some variations of chromium picolinate can irritate the gastrointestinal tract and even lead to ulcers [sources: Merck]. If taken in high doses, chromium picolinate can cause dermatitis and organ damage [source: Any Vitamins].
Chromium picolinate and weight loss have a unique relationship. Read on to find out what that is.