What diseases are associated with tooth loss?

Other Diseases Linked to Periodontal Disease

On the previous page, we discussed the role that bacteria plays in leading to periodontal disease and, sometimes, tooth loss. Researchers believe that bacteria from plaque may get in the bloodstream and go on to damage other parts of the body as well. As a result, gum disease has been associated with a number of chronic conditions:

Cardiovascular diseases: Researchers have long recognized a connection between periodontal disease and cardiovascular diseases. In fact, studies have shown a noteworthy link between gum disease-related tooth loss and the presence of carotid artery plaque, as well as the occurrence of peripheral artery disease [sources: Desvarieux, et. al.; Hung, et. al]. Research in China found that adults with a high number of missing teeth had a 28 percent increased risk of dying from heart disease, and a 12 percent increased risk of dying from a stroke [source: Abnet, et. al].

Cancer: The relationship between periodontal disease and cancer is another one experts have been aware of for some time. However, studies are showing that there are even more potential cancer links than originally suspected. Not only can advanced gum disease possibly lead to oral, lung, pancreatic and upper gastrointestinal cancers, it may also be connected to breast cancer [sources: Meyer, et. al; Soder, et. al].

Dementia: A landmark, ongoing study of aging known as the Nun Study has taught researchers a lot about dementia. One of the things it has brought to light is the possibility that tooth loss can lead to memory loss. While periodontal disease may be responsible for this dementia risk, other causes -- such as childhood nutritional deficiencies -- haven't been ruled out. In fact, the topic is likely to undergo more research before a definitive explanation can be given for the connection [source: American Dental Association].

Chronic kidney disease: Another condition with an obvious but not fully understood relationship with periodontal disease is chronic kidney disease. Studies show that tooth loss is associated with an increased risk of the kidney condition, but experts are unsure if the link is casual or causal [source: American Academy of Periodontology].

Pregnancy risks: Complications associated with periodontal disease and tooth loss can include premature birth, preeclampsia and fetal growth restriction. And not only can periodontal disease cause problems with a woman's pregnancy, but the pregnancy can make the periodontal disease progress faster. To make matters worse, it seems that treatments do not reduce the advancement of periodontal disease during pregnancy. Researchers think this may mean that more aggressive gum disease treatments are necessary for pregnant women, although the issue is still being studied. One certainty, however, is that proper dental care is an important part of prenatal preparations [source: The Canadian Press].

That's a pretty scary list of possibilities. So, it seems that lazy or inefficient oral care can cause more trouble than just a cavity or bad breath. And while some of the connections between periodontal disease and other health conditions are still being researched, it's best to err on the side of caution and follow your dentist's instructions: Brush and floss twice a day and between meals, and visit your dentist for a cleaning and checkup twice a year. To further reduce your risk of gum problems, experts suggest you try to reduce stress, eat a well-balanced diet, stop smoking and find a way to halt tooth grinding [source: WebMD].

Want some more information before heading to the store to stock up on floss and toothpaste? You're in luck: Peruse the resources and links below.

Related Articles


  • Abnet, CC; Qiao, YL; Dawsey, SM; Dong, ZW; Taylor, PR; and SD Mark. "Tooth loss is associated with increased risk of total death and death from upper gastrointestinal cancer, heart disease, and stroke in a Chinese population-based cohort." International Journal of Epidemiology. Oct. 6, 2004. (Oct. 4, 2011) http://ije.oxfordjournals.org/content/34/2/467.full
  • American Academy of Periodontology. "Fallacies about Gum Disease." (Oct. 4, 2011) http://www.perio.org/consumer/f1.html
  • American Academy of Periodontology. "Gum Disease and Osteoporosis." (Oct. 4, 2011) http://www.perio.org/consumer/mbc.osteoporosis.htm
  • American Academy of Periodontology. "Researchers Caution that Tooth Loss May Increase Risk of Chronic Kidney Disease in U.S. Adults." (Oct. 4, 2011) http://www.perio.org/consumer/kidney-disease.htm
  • American Dental Association. "Tooth Loss, Dementia May Be Linked, Study Suggests." ScienceDaily. Oct. 11, 2007 (Oct. 4, 2011) http://www.sciencedaily.com/releases/2007/10/071010111807.htm
  • The Canadian Press. "Gum disease treatment and premature birth risk not linked after all: study." Jan. 30, 2009 (Oct. 4, 2011) http://www.cbc.ca/news/health/story/2009/01/30/gum.html
  • Desvarieux, M; Demmer, RT; Rundek, T; Boden-Albala, B; Jacobs Jr., DR; Papapanou, P; and R. Sacco. "Relationship Between Periodontal Disease, Tooth Loss, and Carotid Artery Plaque: The Oral Infections and Vascular Disease Epidemiology Study (INVEST)." Stroke. April 14, 2003(Oct. 4, 2011) http://stroke.ahajournals.org/content/34/9/2120.full
  • Hung, HC; Willett, W; Merchant, A; Rosner, B; Ascherio, A; and Joshipura, K. "Clinical Investigation and Reports: Oral Health and Peripheral Arterial Disease." Circulation. Nov. 20, 2002 (Oct. 4, 2011) http://circ.ahajournals.org/content/107/8/1152.short
  • Meyer, MS; Joshipura, K; Giovannucci, E; and DS Michaud. "A Review of the Relationship between Tooth Loss, Periodontal Disease, and Cancer." Cancer Causes Control. Nov. 19, 2008 (Oct. 4, 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723958/
  • Soder, B; Yakob, M; Meurman, JH; Andersson, LC; Klinge, B; and PO Soder. "Periodontal disease may associate with breast cancer." Breast Cancer Research and Treatment. June 2011 (Oct. 4, 2011) http://www.ncbi.nlm.nih.gov/pubmed/20960226
  • WebMD. "Gingivitis and Periodontal Disease (Gum Disease)." March 15, 2009 (Oct. 4, 2011) http://www.webmd.com/oral-health/guide/gingivitis-periodontal-disease

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