Understanding the Conception Process

The Embryo Implantation Process

Within the first week after fertilization, the human blastocyst is ready for its new home, the nutrient-rich endometrium.
Within the first week after fertilization, the human blastocyst is ready for its new home, the nutrient-rich endometrium.

Conception is the fertilization of the egg by a sperm cell. If you're a sperm cell entering the vagina, there's about a 1 in 250 million chance you'll be the sperm cell that reaches the egg. Once that occurs, the fertilized egg is known as a zygote.

The initial follicle from which the egg was formed (the corpus luteum) will release progesterone for approximately 14 days [source: N.V. Organon]. This prompts the buildup of blood and nutrients in the uterine wall (endometrium).

Information encoded in the collective DNA of the egg and sperm cell instructs the zygote to continue its development into an embryo. Within 24 hours after forming, a zygote will begin a process of cellular division that will soon lead to exponential cell growth. Very early on, it will develop into a solid cluster of cells, but then it forms a blastocyst, a hollow structure that the mass of cells continues to develop within. The mass of cells inside this structure will be the embryo, while the outer wall will become the placenta and other nutrient-providing tissues needed by the fetus.

The zygote then makes a four-day journey down the fallopian tube toward the uterus, aided again by the tiny hair-like structures lining the tube. After about five days, the zygote will have made its way into the uterus. In one more day's time, this mass of cells will "hatch" from its thin-walled sac.

Now, the blastocyst is ready to make direct contact with the endometrium. When it does, both the endometrium and the blastocyst will exchange hormones, allowing the blastocyst to connect to the uterine wall, a process known as implantation. Women may experience light bleeding or spotting during this process, though it should only last about 48 hours.

As this process occurs, the cervix will be closed with a mucous plug. With the zygote safely in the blood- and nutrient-rich uterine lining, the pregnancy has taken a big step forward. At this point, some of the zygote's cells form the placenta, while others form the developing embryo.

Within about three weeks, the first nerve cells will develop. As the weeks and months roll by, explosive cell growth will occur, and extremely specialized and astoundingly different cells will be created.

Interestingly, if the fetus is female, she very quickly develops millions of immature eggs that she'll carry into adulthood, at which point she can begin this cycle all over again.

See the next page for lots more information on conception.

Related Articles


  • Advanced Fertility Center of Chicago. "Human Blastocyst Embryo Implantation After IVF." (March 11, 2011)http://www.advancedfertility.com/implantation.htm
  • American Pregnancy Association. "Ovulation Frequently Asked Questions." January 2005. (March 11, 2011)http://www.americanpregnancy.org/gettingpregnant/ovulationfaq.htm
  • American Pregnancy Association. "Understanding Ovulation." August 2006. (March 11, 2011)http://www.americanpregnancy.org/gettingpregnant/understandingovulation.html
  • Campbell, Denis. "'Wild, energetic sex is key to conception'." The Observer. March 22, 2009. (March 11, 2011)http://www.guardian.co.uk/lifeandstyle/2009/mar/22/fertility-problems-relationships
  • Harms, Roger W., M.D. "How long do sperm live after ejaculation?" Mayo Foundation for Medical Education and Research. March 13, 2010. (March 20, 2011)http://www.mayoclinic.com/health/pregnancy/AN00281
  • Healthwise. "Semen Analysis." WebMD. Feb. 3, 2009. (March 20, 2011)http://www.webmd.com/infertility-and-reproduction/guide/semen-analysis
  • Lindemann, Charles B., Ph.D. "Dr. Lindemann's Sperm Facts." Oakland University. (March 11, 2011)http://www2.oakland.edu/biology/lindemann/spermfacts.htm
  • The Local. "Human egg gives sperm a 'navigation system.'" March 18, 2011. (March 20, 2011)http://www.thelocal.de/sci-tech/20110318-33809.html
  • Mayo Foundation for Medical Education and Research. "Female fertility: Why lifestyle choices count." March 9, 2010. (March 11, 2011)http://www.mayoclinic.com/health/female-fertility/MY01095
  • Mayo Foundation for Medical Education and Research. "Getting Pregnant: Fertility." March 19, 2011. (March 20, 2011)http://www.mayoclinic.com/health/getting-pregnant/MY00329
  • Mayo Foundation for Medical Education and Research. "Healthy sperm: Improving your fertility." Dec. 16, 2010. (March 11, 2011)http://www.mayoclinic.com/health/fertility/MC00023
  • MedicineNet. "Definition of Fallopian Tube." Feb. 22, 2001. (March 11, 2011)http://www.medterms.com/script/main/art.asp?articlekey=3375
  • Michigan State University. "Scientists Crack Genetic Secrets Of Human Egg." ScienceDaily. Sept. 6, 2006. (March 11, 2011)http://www.sciencedaily.com/releases/2006/09/060905224700.htm
  • National Geographic. "Sizing Up Sperm." (March 11, 2011)http://channel.nationalgeographic.com/episode/sizing-up-sperm-4921/Overview
  • N.V. Organon. "Ready to get pregnant: Her Body." (March 11, 2011) http://www.fertilityjourney.com/ready-to-get-pregnant/months-1-3-take-care-have-fun/her-body/index.asp?C=94478406200117013889
  • Regan, Lesley. "The incredible journey." The Times. Oct. 5, 2005. (March 18, 2011)http://www.timesonline.co.uk/tol/life_and_style/health/article418322.ece
  • University of Maryland Medical Center. "Fetal Development: Overview." Nov. 1, 2009. (March 11, 2011)http://www.umm.edu/ency/article/002398.htm
  • University of Utah, Genetic Science Learning Center. "Using Karyotypes to Predict Genetic Disorders." (March 11, 2011)http://learn.genetics.utah.edu/content/begin/traits/predictdisorder/
  • Von Radowitz, John. "'Daily sex for week boosts conception chance.'" The Independent. June 30, 2009. (March 11, 2011)http://www.independent.co.uk/life-style/love-sex/consummation/daily-sex-for-week-boosts-conception-chance-1724888.html
  • The Washington University School of Medicine. "Hypothalamus and Autonomic Nervous System." Neuroscience Tutorial. (March 11, 2011)http://thalamus.wustl.edu/course/hypoANS.html
  • WebMD. "Conception Slideshow: From Egg to Embryo." March 30, 2010. (March 11, 2011)http://www.webmd.com/baby/slideshow-conception
  • WebMD. "Pregnancy and Conception." 2010. (March 12, 2011)http://www.webmd.com/baby/guide/understanding-conception
  • Womenshealth.gov. "Menstruation and the Menstrual Cycle: Frequently Asked Questions." Oct. 21, 2009. (March 20, 2011)http://www.womenshealth.gov/faq/menstruation.cfm