If you're looking to exact revenge against your uncooperative sebaceous glands, you may choose to take the battle to the next level: lasers.
Lasers utilizing pulsating lights can be focused on problematic parts of the skin, producing heat beneath the skin's surface. This heat causes thermal damage to the sebaceous glands but doesn't damage the surface of your skin. Laser treatment reduces acne by half after just two sessions [source: Friedman].
Be warned that it's not all fun and games, though -- even with a topical painkiller, the treatment may still cause discomfort or pain. You might also experience swelling and redness for a day or two.
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